As early as 1966, Nell and other studies found that blue light irradiation can cause damage to retinal cells, resulting in decreased vision or even loss of vision. Among them, short-wave blue light with a wavelength of 400-450 nanometers is the most harmful to the retina.

At the 2010 annual meeting of the International Optical Association, the world's top optical experts unanimously pointed out that short-wave blue light has extremely high energy and can penetrate the lens and reach the retina. Blue light irradiating the retina will generate free radicals, and these free radicals will lead to the decline of retinal pigment epithelial cells, and the decline of epithelial cells will lead to the lack of nutrients for light-sensitive cells and cause vision damage, and these damages are irreversible.

German ophthalmologist Professor Richard Funk (R.H.W. Funk) research report pointed out that when "inappropriate light" continues to shine on our eyes, it will also cause physical dysfunction.